Tico boston ma12/9/2022 ![]() Landmark analyses showed that the reductions in NACE and TIMI major bleeding seen in the primary results were also seen between 3 and 12 months: Overall, 36% of patients presented with STEMI, 34% with NSTEMI, and 30% with unstable angina. TICO BOSTON MA PLUSInvestigators randomized patients to 12 months of DAPT with ticagrelor plus aspirin or to 3 months of DAPT followed by 9 months of ticagrelor monotherapy. TICO, conducted at 38 Korean centers, included 3,056 patients with ACS (mean age 61 years 79% men) who underwent PCI with the ultrathin-strut, bioresorbable-polymer, sirolimus-eluting Orsiro stent (Biotronik) those at high bleeding risk were excluded. “I think the aspirin makes the bleeding.” ![]() With more-potent P2Y12 inhibitors like ticagrelor and prasugrel, however, in vitro studies show that adding aspirin doesn’t enhance the suppression of platelet activity, and thus the duration of DAPT with aspirin can be shortened, he said. Jang said that if you prolong DAPT, especially with clopidogrel, you may reduce ischemic events. “So I think that core finding is a true one.”īut, he asked Jang, how does one reconcile these findings with prior trials indicating that longer durations of DAPT improve outcomes? “To have two independently done trials essentially reaching the same conclusion that this strategy of ticagrelor monotherapy essentially cuts major bleeding in half is very comforting,” Bhatt said. TICO BOSTON MA TRIAL” That trial also showed that going with ticagrelor monotherapy after 3 months of DAPT reduced bleeding without increasing ischemic events, albeit in a broader population of high-risk PCI patients. “This finding indicates that ticagrelor monotherapy could be an optimal strategy, balancing both ischemic and bleeding risks for patients with ACS treated by ultrathin, biodegradable-polymer, sirolimus-eluting stents,” Jang concluded.Ĭommenting during a panel discussion after Jang’s presentation, Deepak Bhatt, MD (Brigham and Women’s Hospital, Boston, MA), gave a nod toward some of the trial’s limitations cited by Jang-it was open-label, lacked a placebo control, and had limited statistical power-but said TICO “is an important independent confirmation of TWILIGHT. The difference was mainly driven by a reduction in major bleeding (1.7% vs 3.0% HR 0.56 95% CI 0.34-0.91), he reported at the virtual American College of Cardiology (ACC) 2020 Scientific Session. Please call the office at 61 if you are interested in helping plan the event.Switching to ticagrelor (Brilinta AstraZeneca) monotherapy after 3 months of dual antiplatelet therapy (DAPT) reduces major bleeding without increasing ischemic risk compared with 12 months of DAPT in ACS patients implanted with a second-generation DES, results of the TICO trial show.ĭropping aspirin after 3 months reduced the risk of net adverse clinical events (NACE), a composite of TIMI major bleeding and major adverse cardiac and cerebrovascular events, through 1 year (3.9% vs 5.9% HR 0.66 95% CI 0.48-0.92), according to Yangsoo Jang, MD, PhD (Yonsei University College of Medicine, Seoul, Korea). View photos from 2017 Late-Night with Friends View photos from 2017 Dinner with Friends Sponsorships at $2,500 and above available now. Sponsor benefits include event tickets, ads in the program booklet distributed to guests, recognition in Boston magazine and in online and social media, and listingĪs a supporting sponsor of all 2018 Friends’ events. Increase your gift to Dana-Farber’s cutting-edge research and high-quality patient care. ![]() Pastry Director, Eastern Standard Kitchen and Drinks, Hotel CommonwealthĬhef & Owner, Tremont 647 and The Smoke ShopĮxecutive Chef, Dana-Farber Cancer InstituteĬhef & Restaurateur, Sycamore, Little Big Diner, ButtonwoodĬhef & Owner of restaurants across the country, including Doretta Taverna & Raw Bar, Tico BostonĬhef & Owner, Blue Dragon, Chowstirs (Opening 2018) Guests will delight in food, cocktails, and celebrity chef demonstrations from our host, Chef Jeremy Sewall and his celebrity chef friends.Īward-winning chef and co-owner of Island Creek Oyster Bar Boston & Burlington, Row 34 Boston & Portsmouth, and Les Sablons Dinner with Friends celebrates friendship, food, and philanthropy. ![]()
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